Search Result

Search Results for " nerve growth factor "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16766	Ro 08-2750
	Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2...
T6052	GW 441756		Apoptosis , Raf , Trk receptor , CDK
	GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.		Apoptosis , Raf , Trk receptor , CDK
T11861	LM11A-31 dihydrochloride		Others
	LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni...		Others
T4397	DIM-C-pPhOCH3	C-DIM5	Others
	DIM-C-pPhOCH3 (C-DIM5) is a Nerve Growth Factor-Induced Bα (NGFI-Bα, Nur77) agonist		Others
T67980	Coleneuramide	MCC-257	Others
	Coleneuramide (MCC-257) enhances the effect of nerve growth factor (NGF) on cell survival and can be used to study diabetic polyneuropathy.		Others
T9272	Xaliproden hydrochloride		Dopamine Receptor , 5-HT Receptor
	Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist.		Dopamine Receptor , 5-HT Receptor
T73286	SRI-42127		HuR
	SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pa...		HuR
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
T12384	PD 90780		Others
	PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC1...		Others
T17000	Tavilermide	MIM-D3	Trk receptor
	Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.		Trk receptor
T31761	Fellutamide A
	Fellutamide A as a tripeptide derivative from Penicillium fellutanum can enhance nerve growth factor (NGF) synthesis and secretion in vitro.
T33858	PACA	N-Propargyl Caffeamide
	PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor...
T24272	KT5926	KT 5926,KT-5926
	KT5926 is an effective and selective inhibitor of myosin light chain kinase. KT5926 is an analogue of K-252a, which blocks all responses to NGF. KT5926 selectively inhibits nerve growth factor-dependent neurite elongatio...
T12669	(Rac)-LM11A-31 dihydrochloride		Others
	(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride is a potent antagonist of proNGF (nerve growth factor).		Others
T29598	Acetylcarnitine arginyl amide	ST-857,acetyl-L-carnitine arginine amide
	Acetylcarnitine arginyl amide is able to stimulate neurite outgrowth in a manner similar to that elicited by nerve growth factor (NGF). Neurite induction by this molecule requires de novo mRNA synthesis and is independen...
T82367	Fulranumab
	Fulranumab, a human IgG2 monoclonal antibody targeting nerve growth factor (NGF), is utilized in pain research [1].
T29543	ACAF4	ACAF-4,ACAF 4
	ACAF4 is a neurotrophic agent which significantly increases survival in PC12 neuronal cells and enhances the effect of nerve growth factor (NGF). ACAF4 induces neurite outgrowth, and modulates ERK1/2 and AKT signaling pa...
T77142	Ranevetmab
	Ranevetmab (NV-01), a caninized anti-nerve growth factor (anti-NGF) monoclonal antibody (mAb), is utilized in research for alleviating pain associated with degenerative joint disease (DJD) in canines.
T78280	Fasinumab
	Fasinumab (Anti-Human NGF), a human IgG1κ monoclonal antibody targeting nerve growth factor (NGF), has applications in clinical studies for acute sciatica and knee osteoarthritis (OA) [1].
T78316	Frunevetmab	NV-02
	Frunevetmab (NV-02), a felinized monoclonal antibody targeting nerve growth factor (NGF), exhibits a high affinity with a dissociation constant (Kd) of 20 pM and has been demonstrated to effectively mitigate osteoarthrit...
T63346	TRK-IN-18
	TRK-IN-18 is a potent inhibitor of TRK. Among them are promyosin-related kinases (Trks), a family of receptor tyrosine kinases activated by neurotrophic factors, a group of soluble growth factors containing nerve growth ...
T62561	TRK-IN-17
	TRK-IN-17 is a potent inhibitor of TRK. Among them is promyosin-related kinase (Trks), a member of the receptor tyrosine kinase family, which is activated by neurotrophic factors. Neurotrophic factors are a group of solu...
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841), a canine monoclonal antibody (mAb) designed to target nerve growth factor (NGF), prevents NGF from interacting with its receptors, tropomyosin receptor kinase A (trkA) and p75 neurotrophin rec...
T63965	Bepotastine tosylate
	Bepotastine tosylate is a selective, orally active second-generation histamine H1 receptor antagonist that exhibits an inhibitory effect on histamine-mediated upregulation of nerve growth factor (NGF) expression. conjunc...
T78282	Tanezumab	RN-624,PF 4383119
	Tanezumab (RN-624) is a high-affinity, specific humanized anti-NGF monoclonal antibody (mAb) that inhibits nerve growth factor (NGF) from binding to its p75 and TrkA receptors in the peripheral nervous system. It is util...

Compounds

Target: Apoptosis, Raf, Trk receptor, CDK

LM11A-31 dihydrochloride

Xaliproden hydrochloride

T9272

Synonym:

Target: Dopamine Receptor, 5-HT Receptor

Synonym: N-Propargyl Caffeamide

Target:

KT5926

T24272

Synonym: KT 5926,KT-5926

Target:

(Rac)-LM11A-31 dihydrochloride

T12669

Synonym:

Target: Others

Acetylcarnitine arginyl amide

T29598

Synonym: ST-857,acetyl-L-carnitine arginine amide

Synonym: ACAF-4,ACAF 4

Synonym: RN-624,PF 4383119

Target:

Cat No.	Product Name	Synonyms	Targets
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T82446	Erinacine C
	Erinacine C, a potent stimulator, promotes the synthesis of nerve-growth factor (NGF) [1].
TN4123	Gelsemiol		Others
	Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor.		Others
T81814	Methyl Ganoderic acid B
	Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].
TN4126	Gentiside B		Others
	Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) conc...		Others
T81676	NG-012
	NG-012, a nerve growth factor (NGF) potentiator, was isolated from the culture broth of Penicillium verruculosum F-4542. It enhances neurite outgrowth as induced by NGF in the rat pheochromocytoma cell line (PC12) [1].
T81980	Kissoone C
	Kissoone C (compound 3), a sesquiterpene with a three-membered ring structure, has been isolated from valerian root. This compound has been found to promote nerve growth factor (NGF)-mediated neurite outgrowth in PC12D c...
TN4291	Isofuranodiene		IL Receptor , NOS
	Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting...		IL Receptor , NOS

Natural Products

Negletein

T2S0843

Synonym: 7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Eudesmin

T3836

Synonym:

Target: MAPK, S6 Kinase

Methyl Ganoderic acid B

Target: IL Receptor, NOS

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01469	NGF Protein, Human, Recombinant (E. colli)	Mouse	E. coli
	NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family ...
TMPJ-01468	Pro-Beta NGF Protein, Human, Recombinant	Human	E. coli
	The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite...
TMPY-01010	NGF Protein, Human, Recombinant	Human	CHO Cells
	NGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.2 kDa and the accession number is P01138.
TMPY-06985	NGF Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138.
TMPY-02614	NGFR/p75NTR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is P08138.
TMPY-01402	NGF Protein, Mouse, Recombinant	Mouse	CHO Cells
	NGF Protein, Mouse, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P01139.
TMPY-06973	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.03 kDa and the accession number is XP_005583674.1.
TMPY-06959	NGFR/p75NTR Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	NGFR/p75NTR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.34 kDa and the accession number is P07174.
TMPY-04646	NGFR/p75NTR Protein, Rabbit, Recombinant (His)	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is XP_008269543.1.
TMPY-04831	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is XP_008269543.1.
TMPY-02588	NGFR/p75NTR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is Q9Z0W1.
TMPJ-00883	EGR1 Protein, Human, Recombinant (His)	Human	E. coli
	EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The produc...
TMPY-02541	NGFR/p75NTR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Z0W1.
TMPY-02615	NGFR/p75NTR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is P08138.
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I...
TMPY-04069	Neurotrophin 3 Protein, Human, Recombinant	Human	E. coli
	NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate...
TMPK-00774	TrkA Protein, Human, Recombinant (aa 33-417, His)	Human	HEK293 Cells
	TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signa...
TMPY-03216	GMF beta/GMFB Protein, Human, Recombinant	Human	E. coli
	GMFB is a nerve growth factor which belongs to the actin-binding proteins ADF family, GMF subfamily. GMFB is involved in nervous system development, angiogenesis and immune function. It is especially crucial for the nerv...
TMPJ-00024	GMF beta/GMFB Protein, Human, Recombinant (His)	Human	E. coli
	Glia maturation factor beta (GMFB) contains a ADF-H domain，which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis and...
TMPJ-00054	PLGF-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF f...
TMPY-01695	CASPR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor re...
TMPY-02579	NRN1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervo...
TMPJ-00821	OM Protein, Human, Recombinant (His)	Human	E. coli
	Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macropha...
TMPY-01438	FLRT3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Leucine-rich repeat transmembrane protein FLRT3, also known as Fibronectin-like domain-containing leucine-rich transmembrane protein 3, and FLRT3, is a single-pass type I membrane protein which belongs to the fibronectin...